Enabling earlier diagnosis, with greater accuracy, at low levels of the healthcare system.

Fever syndromes account for over 1 billion episodes annually and are one of the most common reasons to seek care worldwide. For the nearly 3 billion people who live in the equatorial belt a high fever can signal the onset of potentially deadly infectious diseases. E25Bio Inc. is a Tough Tech company based at The Engine developing Rapid Diagnostic Tests for fever. Existing solutions rely heavily on centralized laboratory equipment and trained staff, cold chain for specimen transport, and hub-and-spoke reporting mechanisms for data. Our innovations aim to provide people with a much simpler alternative: to identify infectious diseases in time to avoid serious complications and death. Through early and accurate screening, we can help equip the right patient with the right treatment at the right time.


Our innovation starts with an antibody discovery process that is 70% faster than current methods. We use this to scientifically iterate faster and find better-performing antibody pairs more predictably. We then translate these optimal antibody pairs into cheaper, point-of-care Rapid Diagnostic Tests. Our approach enables patients to use their own diagnosis of “high fever” to trigger a self-test at home, instead of requiring a clinician to first perform an examination and central lab referral. This technology democratizes first-line defense against fever-causing infectious diseases.

Our Team

Jeff Takle, MBA

CEO & Co-Founder

Irene Bosch, PhD

CTO & Co-Founder

Bobby Brooke Herrera, PhD

CSO & Co-Founder


Operations Manager

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